Prediction of Intrinsically Unstructured Proteins
Intrinsically disordered proteins (IDPs) have no single well-defined tertiary structure
under native
conditions. IUPred2A is a combined web interface that allows to identify disordered
protein
regions
using IUPred2 and disordered binding regions using ANCHOR2. IUPred2A is also capable of
identifying
protein regions that do or do not adopt a stable structure depending on the redox state
of
their
environment. IUPred2A supersedes the previous
IUPred and
ANCHOR servers. For new features
included in IUPred2A, see the New features
section.
For a detailed description of how to run IUPred2A using various features and how to interpret the output, see the How to use and Examples sections. For a simple demonstration of how to input data, see the example 1 or example 2.
For a detailed description of how to run IUPred2A using various features and how to interpret the output, see the How to use and Examples sections. For a simple demonstration of how to input data, see the example 1 or example 2.
Prediction
References
Primary citations
Bálint Mészáros, Gábor Erdős, Zsuzsanna Dosztányi
IUPred2A: context-dependent prediction of protein disorder as a function of redox state and protein binding
Nucleic Acids Research 2018;46(W1):W329-W337.
Gábor Erdős, Zsuzsanna Dosztányi
Analyzing Protein Disorder with IUPred2A
Current Protocols in Bioinformatics 2020;70(1):e99
Additional citations
Zsuzsanna Dosztányi
Prediction of protein disorder based on IUPred
Protein Science 2017;27:331-340.
Dosztányi Z, Csizmók V, Tompa P, Simon I.
The pairwise energy content estimated from amino acid composition discriminates between folded and intrinsically unstructured proteins
J Mol Biol. 2005;347:827-39.
Mészáros B, Simon I, Dosztányi Z.
Prediction of protein binding regions in disordered proteins
PLoS Comput Biol. 2009;5:e1000376.
Bálint Mészáros, Gábor Erdős, Zsuzsanna Dosztányi
IUPred2A: context-dependent prediction of protein disorder as a function of redox state and protein binding
Nucleic Acids Research 2018;46(W1):W329-W337.
Gábor Erdős, Zsuzsanna Dosztányi
Analyzing Protein Disorder with IUPred2A
Current Protocols in Bioinformatics 2020;70(1):e99
Additional citations
Zsuzsanna Dosztányi
Prediction of protein disorder based on IUPred
Protein Science 2017;27:331-340.
Dosztányi Z, Csizmók V, Tompa P, Simon I.
The pairwise energy content estimated from amino acid composition discriminates between folded and intrinsically unstructured proteins
J Mol Biol. 2005;347:827-39.
Mészáros B, Simon I, Dosztányi Z.
Prediction of protein binding regions in disordered proteins
PLoS Comput Biol. 2009;5:e1000376.