2020 Jul 13
  • Updated the database to represent the latest UniProt release
  • Fixed a bug when UniProt Entry inputs were not treated correctly
2018 Dec 17
  • Major ANCHOR2 rework
    • Reverted the change introduced at Jul 13, ANCHOR2 now produces identical output to original publication
  • Major REDOX prediction rework
    • Redox prediction was changed in multiple ways. For details see:
      Large-scale analysis of redox-sensitive conditionally disordered protein regions reveals their widespread nature and key roles in high-level eukaryotic processes
      Gabor Erdos, Balint Meszaros, Dana Reichmann, Zsuzsanna Dosztanyi
      PROTEOMICS, in press
    • Added an option to Download page to download the Redox predictor
2018 Sep 3
  • Fixed a bug about glob mode producing errors when no globular region is found
2018 Jul 13
  • Major ANCHOR2 rework
    • Removed the IUPred2 smoothing step from ANCHOR2
  • Lowercase amino acid sequence input is now processed correctly
2018 Jul 10
  • Fixed a bug when text based output was not displaying the given protein
2018 Jun 12
  • Fixed a bug when REST interface was not producing output
Primary citations

Bálint Mészáros, Gábor Erdős, Zsuzsanna Dosztányi
IUPred2A: context-dependent prediction of protein disorder as a function of redox state and protein binding
Nucleic Acids Research 2018;46(W1):W329-W337.

Gábor Erdős, Zsuzsanna Dosztányi
Analyzing Protein Disorder with IUPred2A
Current Protocols in Bioinformatics 2020;70(1):e99

Additional citations

Zsuzsanna Dosztányi
Prediction of protein disorder based on IUPred
Protein Science 2017;27:331-340.

Dosztányi Z, Csizmók V, Tompa P, Simon I.
The pairwise energy content estimated from amino acid composition discriminates between folded and intrinsically unstructured proteins
J Mol Biol. 2005;347:827-39.

Mészáros B, Simon I, Dosztányi Z.
Prediction of protein binding regions in disordered proteins
PLoS Comput Biol. 2009;5:e1000376.